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The Analytical Chemistry Shared Resource (ACSR) provides Cancer Center investigators with centralized resources and expertise in performing analytical chemistry assays and pharmacokinetic and pharmacodynamic data analysis and interpretation. The Analytical Chemistry Shared Resource has been built around chromatography based instrumentation which provides the sensitivity and selectivity needed for the analysis of small molecules in pre-clinical drug discovery, chemical structure ID/confirmation, and analysis of inorganic chemicals.
Specifically, the ACSR has the following aims:
To provide Cancer Center investigators with support in the development of chromatography-based analytical methods;
To provide Cancer Center investigators with support in routine quantitative analysis of clinical and pre-clinical samples;
To provide consultation in pharmacokinetic trial design and pharmacokinetic and pharmacodynamic data analysis.
By continuing to provide state-of-the-art analytical and pharmacokinetic services, the ACSR laboratory should greatly augment pre-clinical drug discovery efforts and stimulate the incorporation of pharmacokinetic endpoints in clinical trials.
Services
Consultation on study design including selection of existing assays and/or development of new assays
Development and implementation of analytical chemistry methods for quantification of cancer therapeutic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in biospecimens
Quantitative analysis of cancer therapeutic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in clinical and pre-clinical specimens
Pharmacokinetic study design and pharmacokinetic and pharmacodynamic data analysis
Targeted metabolomic analysis and untargeted metabolomic profiling
Services provided by the ACSR are essential for the assessment of drug/nutrient/carcinogen exposure and disposition, and for the measurement of endogenous biochemicals as surrogate cancer-risk biomarkers and endpoint biomarkers in intervention studies. These measurements are indispensable in many established lines of research in the UACC, including preclinical and clinical evaluation of cancer therapeutic drugs and preventive interventions, assessment of biological, environmental, and lifestyle factors associated with cancer risk and disease progression, and identification of potential targets for intervention.
Equipment/Instruments
State-of-the-art equipment and sophisticated analytical chemistry techniques are provided by the ACSR to cover a broad variety of needs. Personnel are trained experts in the operation and maintenance of this equipment. They have the expertise to develop and optimize the appropriate methods. Available equipment includes:
Liquid Chromatography-Mass Spectrometry (LC-MS)
Gas Chromatography-Mass Spectrometry (GC-MS)
Atomic Absorption Spectrophotometry (AAS)
High Performance Liquid Chromatography (HPLC)
Ultra Performance Liquid Chromatography – Quadrupole/Time of
Flight Mass Spectrometry (UPLC-QTOF)
The Experimental Mouse Shared Resource (EMSR) has provided expertise to The University of Arizona Cancer Center and outside investigators since 1993. Good Lab Practice (GLP) qualified since 2012, the EMSR offers a continuum of services from initial consultation and in vivo experimental design, mouse experimentation and data analysis. The EMSR enables the investigator to generate and use rodent models to their fullest potential, utilizing the service’s extensive knowledge and expertise at competitive pricing. The EMSR helps to develop cancer therapies that are efficient, cost effective, and clinically relevant. The EMSR is a full-service facility, which performs preclinical experiments in a wide variety of in vivo and in vitro cancer models. The team provides technical and scientific expertise in modeling of cancer disease and assists in developing efficient, cost effective, and clinically relevant drug therapies. Services provided:
*Animal techniques (drug testing, rodent acute toxicity, and pharmacokinetics)
*Patient-derived xenograft (PDX models)
*Surgeries (orthotopic injections, ovariectomy, window chambers, etc.)
*Mouse colonies maintenance
*Cell culture
*Xenograft and GEM models tissue bank
*IACUC protocol support
*Administrative support
The Tissue Acquisition and Cellular / Molecular Analysis Shared Resource (TACMASR) provides support and pathology-related services to University of Arizona Cancer Center (UACC) and University of Arizona (UA) researchers on a fee-for-service basis. We strive to maximize research dollars through customized, cost-effective, and quality-controlled services.TACMASR offers two primary types of services to UACC and UA research investigators that include Cellular and molecular analysis and Tissue acquisition and biobanking.
| Sherry Chow, Ph.D. | ACSR Director | 520-626-3358 | |
| Wade Chew | ACSR Manager | 520-626-2331 | |
| Natalia Ignatenko | EMSR Co-Director | 520-626-2346 | UACC-EMSS@email.arizona.edu |
| Gillian Paine-Murrieta | EMSR Manager | 520-626-2346 | UACC-EMSS@email.arizona.edu |
| Ron Lynch, PhD. | TACMASR Director | 520-626-2472 | rlynch@email.arizona.edu |
| Hours: | Location: |
|
Analytical Chemistry: Monday-Friday 8am-5pm
EMSR: Monday-Friday 8:30am-4:30PM
TACMASR: Moday-Friday 8am-5pm |
Analytical Chemistry: 1515 N Campbell Ave, Rm 4965 Tucson, AZ. 85724
EMSR: 1515 N Campbell Ave. Tucson, AZ. 85724
TACMASR: 1515 N Campbell Ave Tucson, AZ. 85724 |
*Analytical Chemistry Core is staffed 6am-3pm
| Name | Role | Phone | Location | |
|---|---|---|---|---|
| Wade Chew |
ACSR Manager
|
520-626-2331
|
wchew@email.arizona.edu
|
UACC room 4965
|
| Sherry Chow |
ACSR Director
|
520-626-3358
|
schow@email.arizona.edu
|
UACC room 4977a
|
| Natalia Ignatenko |
EMSR Co-Director
|
520-626-2346
|
UACC-EMSS@email.arizona.edu
|
AZCC
|
| Gillian Paine-Murrieta |
EMSR Manager
|
520-626-2346
|
UACC-EMSS@email.arizona.edu
|
AZCC
|
| Jocelyn Fimbres |
TACMASR Histologist
|
520-626-7319
|
jocelynf@email.arizona.edu
|
UACC 0917
|
| Ali Hussaini |
TACMASR Histologist
|
520-626-7319
|
hussaini@email.arizona.edu
|
UACC 0917
|
| Betsy Dennison |
TACMASR Lab Manager
|
520-626-0326
|
betsyd@email.arizona.edu
|
UACC 0914A
|
| Carole Kepler |
TACMASR Biorep collections
|
520-626-7319
|
CKepler@uacc.arizona.edu
|
|
| TACMASR email |
UACC-TACMASS@uacc.arizona.edu
|
