AZ Cancer Center Basic Science Shared Resources

Overview of Services

The University of Arizona Cancer Center Analytical Chemistry Shared Resource (ACSR) provides Cancer Center investigators with centralized resources and expertise in performing analytical chemistry assays and pharmacokinetic and pharmacodynamic data analysis and interpretation. The Analytical Chemistry Shared Resource has been built around chromatography based instrumentation which provides the sensitivity and selectivity needed for the analysis of small molecules in pre-clinical drug discovery, chemical structure ID/confirmation, and analysis of inorganic chemicals.

 

Specifically, the ACSR has the following aims:

 

To provide Cancer Center investigators with support in the development of chromatography-based analytical methods;

To provide Cancer Center investigators with support in routine quantitative analysis of clinical and pre-clinical samples;

To provide consultation in pharmacokinetic trial design and pharmacokinetic and pharmacodynamic data analysis.

By continuing to provide state-of-the-art analytical and pharmacokinetic services, the ACSR laboratory should greatly augment pre-clinical drug discovery efforts and stimulate the incorporation of pharmacokinetic endpoints in clinical trials.

 

Services

Consultation on study design including selection of existing assays and/or development of new assays

Development and implementation of analytical chemistry methods for quantification of cancer therapeutic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in biospecimens

Quantitative analysis of cancer therapeutic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in clinical and pre-clinical specimens

Pharmacokinetic study design and pharmacokinetic and pharmacodynamic data analysis

Targeted metabolomic analysis and untargeted metabolomic profiling

Services provided by the ACSR are essential for the assessment of drug/nutrient/carcinogen exposure and disposition, and for the measurement of endogenous biochemicals as surrogate cancer-risk biomarkers and endpoint biomarkers in intervention studies. These measurements are indispensable in many established lines of research in the UACC, including preclinical and clinical evaluation of cancer therapeutic drugs and preventive interventions, assessment of biological, environmental, and lifestyle factors associated with cancer risk and disease progression, and identification of potential targets for intervention.

 

 

Equipment/Instruments

State-of-the-art equipment and sophisticated analytical chemistry techniques are provided by the ACSR to cover a broad variety of needs. Personnel are trained experts in the operation and maintenance of this equipment. They have the expertise to develop and optimize the appropriate methods. Available equipment includes:

 

Liquid Chromatography-Mass Spectrometry (LC-MS)

Gas Chromatography-Mass Spectrometry (GC-MS)

Atomic Absorption Spectrophotometry (AAS)

High Performance Liquid Chromatography (HPLC)

Ultra Performance Liquid Chromatography – Quadrupole/Time of

Flight Mass Spectrometry (UPLC-QTOF)

 

 

The Experimental Mouse Shared Resource (EMSR) has provided expertise to The University of Arizona Cancer Center and outside investigators since 1993. Good Lab Practice (GLP) qualified since 2012, the EMSR offers a continuum of services from initial consultation and in vivo experimental design, mouse experimentation and data analysis. The EMSR enables the investigator to generate and use rodent models to their fullest potential, utilizing the service’s extensive knowledge and expertise at competitive pricing. The EMSR helps to develop cancer therapies that are efficient, cost effective, and clinically relevant. The EMSR is a full-service facility, which performs preclinical experiments in a wide variety of in vivo and in vitro cancer models. The team provides technical and scientific expertise in modeling of cancer disease and assists in developing efficient, cost effective, and clinically relevant drug therapies. Services provided:

 

*Animal techniques (drug testing, rodent acute toxicity, and pharmacokinetics)
*Patient-derived xenograft (PDX models)
*Surgeries (orthotopic injections, ovariectomy, window chambers, etc.)
*Mouse colonies maintenance
*Cell culture
*Xenograft and GEM models tissue bank
*IACUC protocol support
*Administrative support

 

The Tissue Acquisition and Cellular / Molecular Analysis Shared Resource (TACMASR) provides support and pathology-related services to University of Arizona Cancer Center (UACC) and University of Arizona (UA) researchers on a fee-for-service basis. We strive to maximize research dollars through customized, cost-effective, and quality-controlled services.TACMASR offers two primary types of services to UACC and UA research investigators that include Cellular and molecular analysis and Tissue acquisition and biobanking.

Leadership

Sherry Chow, Ph.D. ACSR Director 520-626-3358  
Wade Chew ACSR Manager 520-626-2331  
Natalia Ignatenko EMSR Co-Director 520-626-2346 UACC-EMSS@email.arizona.edu
Gillian Paine-Murrieta EMSR Manager 520-626-2346 UACC-EMSS@email.arizona.edu
Ron Lynch, PhD. TACMASR Director 520-626-2472 rlynch@email.arizona.edu


Location and hours of operation

Hours: Location:

Analytical Chemistry: 

Monday-Friday 

 8am-5pm 

 

EMSR:

Monday-Friday

 8:30am-4:30PM

 

TACMASR:

Moday-Friday

8am-5pm

 Analytical Chemistry:

1515 N Campbell Ave, Rm 4965 

 Tucson, AZ. 85724

 

EMSR:

1515 N Campbell Ave.

 Tucson, AZ. 85724

 

TACMASR:

1515 N Campbell Ave

Tucson, AZ. 85724

 

*Analytical Chemistry Core is staffed 6am-3pm

Links and Resources

  1. Analytical Chemistry Shared Resource
  2. Experimental Mouse Shared Resource (EMSR)
  3. Tissue Acquisition and Cellular/Molecular Analysis Shared Resource
  4. The University of Arizona Cancer Center

Contacts

Name Role Phone Email Location
Wade Chew
ACSR Manager
 
520-626-2331
 
wchew@email.arizona.edu
 
UACC room 4965
 
Sherry Chow
ACSR Director
 
520-626-3358
 
schow@email.arizona.edu
 
UACC room 4977a
 
Natalia Ignatenko
EMSR Co-Director
 
520-626-2346
 
UACC-EMSS@email.arizona.edu
 
AZCC
 
Gillian Paine-Murrieta
EMSR Manager
 
520-626-2346
 
UACC-EMSS@email.arizona.edu
 
AZCC
 
Jocelyn Fimbres
TACMASR Histologist
 
520-626-7319
 
jocelynf@email.arizona.edu
 
UACC 0917
 
Ali Hussaini
TACMASR Histologist
 
520-626-7319
 
hussaini@email.arizona.edu
 
UACC 0917
 
Betsy Dennison
TACMASR Lab Manager
 
520-626-0326
 
betsyd@email.arizona.edu
 
UACC 0914A
 
Carole Kepler
TACMASR Biorep collections
 
520-626-7319
 
CKepler@uacc.arizona.edu
 

 
TACMASR email

 

 
UACC-TACMASS@uacc.arizona.edu
 

 

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